Press Release

One-Dose Adjuvant Saves Time, Cost by Removing Need for Booster Shots

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  • Mar 22, 2021

One-Dose Adjuvant Saves Time, Cost by Removing Need for Booster Shots

Newport Laboratories, Inc., a leader in custom-made vaccines, is proud to offer Bio One™, a proprietary one-dose adjuvant that helps reduce time, labor and expense by removing the need for booster shots.

Many bovine custom-made vaccines require an initial administration and a second booster shot several weeks later, but due to the added labor cost and logistical challenges associated with administering the second dose, it is commonly overlooked. This can compromise the effectiveness of the vaccine.

BIO ONE, which is available exclusively from Newport Laboratories, delays the elimination of antigens, and thus permits immune responses to last longer,1 removing the need for a second dose.

“Making it easier for producers and veterinarians to keep their herds healthy is at the core of what we do at Newport Laboratories,” said Randy Shirbroun, DVM, Director of the Ruminant Business Unit at Newport Laboratories. “We’ve heard from our customers that administering a second dose of a vaccine is time consuming and costly, so we’re excited that BIO ONE will remove that extra step.”

The Key Role of Adjuvants 

There are two basic ingredients in killed vaccines: antigens and adjuvants. Antigens are viruses or bacteria that have been inactivated so they don’t cause disease. But even in an inactivated state, antigens do set off an alarm within the immune system, signaling that a foreign invader is present. It’s the job of the adjuvant to amplify that alarm, which allows the immune system to begin building up its defenses against the invader, making it better prepared to fend off the real thing.

Unlike off-the-shelf killed vaccines, custom-made vaccines give producers and veterinarians the option to select an adjuvant that can help solve their particular herd’s health challenges. Determining the optimal adjuvant to use in a vaccine is critical, because different adjuvants have different abilities when triggering immune responses.2

To learn more about how you can reduce stress in your herd and start saving time with BIO ONE, contact your Newport Laboratories or Boehringer Ingelheim representative, or click here.


1 National Institute of Allergy and Infectious Diseases (NIH). Vaccine adjuvants. 2019. Available at: http://www.niaid.nih.gov/research/vaccine-adjuvants. Accessed April 12, 2019.

2 Krishnan L, Dicaire CJ, Patel GB, Sprott GS. Archaeosome vaccine adjuvants induce strong humoral, cell-mediated and memory responses: comparison to conventional liposomes and alum. Infection and Immunity 2000;68(1):54–63. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC97101/pdf/ii000054.pdf. Accessed April 12, 2019.

BIO ONE™ is a trademark of Newport Laboratories, Inc. ©2021 Newport Laboratories, Inc., Worthington, MN. All Rights Reserved. US-BOV-0157-2021