Press Release

Pinkeye: New Challenges Call for New Solutions

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  • Mar 26, 2021

Pinkeye: New Challenges Call for New Solutions

Cattle herds exposed to infectious bovine keratoconjunctivitis, more commonly known as pinkeye, are at risk of lower calf-growth rate, potential blindness and permanent damage if left untreated.1 It’s estimated that pinkeye causes annual losses of more than $150 million in the United States, affecting over 10 million calves.

With an emerging species of pinkeye bacteria overtaking the previously predominant species, controlling this increasingly complex disease is challenging for many producers and veterinarians. But there are tools that can help.

What the Disease Looks Like

Pinkeye is a nonseasonal infectious disease of ruminants that affects both dairy and beef cattle. When irritants cause damage to the cornea of the bovine eye, pinkeye pathogens attack the damaged cornea, resulting in the following four stages of infection: 

Stage 1 – The initial clinical signs of pinkeye include discoloration of the cornea and tearing up in attempt to flush away the irritant. Discoloration is caused by inflammation, making the eye appear slightly cloudy or gray. A corneal ulcer will often appear in the center of the cornea. Additional clinical signs include squinting or fluttering eyelids, sensitivity to light and more. 

When gathering diagnostic samples for testing, it is best to collect them at this stage, upon the first signs of tearing up.

Stage 2 – Existing clinical signs may worsen, making the eye appear cloudier from increased inflammation. The ulcer expands across the cornea, and blood vessels extend to the eye in an attempt to repair the damaged area, which causes redness (the source of the nickname “pinkeye”). 

Stage 3 – Inflammation spreads to the inner part of the eye as the ulcer begins to cover most of the cornea. The interior of the eye begins to yellow and fills with fibrin, a pus-like substance.

Stage 4 – The ulcer extends through the entirety of the cornea, potentially causing glaucoma, damage to the iris and persistent swelling of the eye. The eye will be at least partially blind, and full blindness could occur if the eye ruptures. 

Increasing Complexity 

For many years, Moraxella bovis (M. bovis) was the predominant species of bacteria associated with pinkeye circulating in cattle herds.2 About 15 years ago, however, veterinarians in the field began reporting increased cases of pinkeye due to an emerging species, Moraxella bovoculi (M. bovoculi), which is now more frequently detected than M. bovis.2 And more recently, researchers identified Mycoplasma bovoculi as a bacteria associated with pinkeye.3 

Most commercial pinkeye vaccines provide protection against M. bovis, but were not developed to cover M. bovoculi, and no commercial vaccines exist for Mycoplasma bovoculi. To make matters worse, anecdotal reports from the field suggest M. bovoculi can be a more aggressive species and progress more rapidly than M. bovis, underscoring the need for producers and veterinarians to take steps toward controlling the disease.
The Solution

Custom-made vaccines provide an option to help producers and veterinarians fight various bacterial causes of pinkeye. A key first step is identifying the specific species of pinkeye pathogens infecting a herd, such as M. bovis, M. bovoculi or Mycoplasma bovoculi. Through diagnostics, Newport Laboratories, Inc. can tell producers and veterinarians the species and the strains they’re dealing with, and use that information to develop a custom-made vaccine specifically targeted at the species and strains present in a herd. For more information, contact your Newport Laboratories representative or click here.


1Snowder GD, Van Vleck LD, Cundiff LV, Bennett GL. Genetic and environmental factors associated with incidence of infectious bovine keratoconjunctivitis in preweaned beef calves. J Anim Sci 2005;833:507–518.

2Loy JD, Brodersen BW. Moraxella spp. isolated from field outbreaks of infectious bovine keratoconjunctivitis: a retrospective study of case submissions from 2010 to 2013. J Vet Diagn Invest 2014;26(6):761–768. 

3Levisohn, S., Garazi, S., Gerchman, I., & Brenner, J. (2004). Diagnosis of a Mixed Mycoplasma Infection Associated with a Severe Outbreak of Bovine Pinkeye in Young Calves. Journal of Veterinary Diagnostic Investigation, 16(6), 579–581.

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